Replication of associations between GWAS SNPs and melanoma risk in the Population Architecture using Genomics and Epidemiology (PAGE) study
نویسندگان
چکیده
Jonathan M Kocarnik1, S Lani Park2, Jiali Han3,4, Logan Dumitrescu5,6, Iona Cheng7, Lynne R Wilkens2, Fredrick R Schumacher8, Laurence Kolonel2, Chris S Carlson1, Dana C Crawford5,6, Robert J Goodloe5, Holli Dilks5, Paxton Baker5, Danielle Richardson5, José Luis Ambite9, Fengju Song3,10, Abrar A Quresh11, Mingfeng Zhang11, David Duggan12, Carolyn Hutter13, Lucia A Hindorff14, William S Bush5,15, Charles Kooperberg1, Loic Le Marchand2, and Ulrike Peters1 1Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 2Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 3Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
منابع مشابه
Pleiotropic and Sex-Specific Effects of Cancer GWAS SNPs on Melanoma Risk in the Population Architecture Using Genomics and Epidemiology (PAGE) Study
BACKGROUND Several regions of the genome show pleiotropic associations with multiple cancers. We sought to evaluate whether 181 single-nucleotide polymorphisms previously associated with various cancers in genome-wide association studies were also associated with melanoma risk. METHODS We evaluated 2,131 melanoma cases and 20,353 controls from three studies in the Population Architecture usin...
متن کاملAssociations between incident ischemic stroke events and stroke and cardiovascular disease-related genome-wide association studies single nucleotide polymorphisms in the Population Architecture Using Genomics and Epidemiology study.
BACKGROUND Genome-wide association studies (GWAS) have identified loci associated with ischemic stroke (IS) and cardiovascular disease (CVD) in European-descent individuals, but their replication in different populations has been largely unexplored. METHODS AND RESULTS Nine single nucleotide polymorphisms (SNPs) selected from GWAS and meta-analyses of stroke, and 86 SNPs previously associated...
متن کاملGenetic risk factors for body mass index and obesity in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) Study
OBJECTIVE Several genome-wide association studies (GWAS) have demonstrated that common genetic variants contribute to obesity. However, studies of this complex trait have focused on ancestrally European populations, despite the high prevalence of obesity in some minority groups. DESIGN AND METHODS As part of the "Population Architecture using Genomics and Epidemiology (PAGE)" Consortium, we i...
متن کاملGenetic Determinants of Lipid Traits in Diverse Populations from the Population Architecture using Genomics and Epidemiology (PAGE) Study
For the past five years, genome-wide association studies (GWAS) have identified hundreds of common variants associated with human diseases and traits, including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) levels. Approximately 95 loci associated with lipid levels have been identified primarily among populations of European anc...
متن کاملReplication of genetic loci for ages at menarche and menopause in the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) study.
STUDY QUESTION Do genetic associations identified in genome-wide association studies (GWAS) of age at menarche (AM) and age at natural menopause (ANM) replicate in women of diverse race/ancestry from the Population Architecture using Genomics and Epidemiology (PAGE) Study? SUMMARY ANSWER We replicated GWAS reproductive trait single nucleotide polymorphisms (SNPs) in our European descent popul...
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